Nigrostriatal pathway Study guides, Class notes & Summaries
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NURS 660 Exam1 LATEST UPDATE 2023 QUESTIONS AND EXPLAINED ANSWERS|AGRADE
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NURS 660 Exam1 LATEST UPDATE 2023 
QUESTIONS AND EXPLAINED 
ANSWERS|AGRADE 
1. Identify the emerging neurobiological hypothesis of schizophrenia. 
o The hypothesis: (focus on the most detail with the Dopamine Theory) 
 The only pharmacological treatment that we have are dopamine (D2 
receptors) and serotonin (5HT2A) 
 Dopamine Theory 
▪ Hyperactive dopamine at D2 receptors in the mesolimbic 
pathway 
In the mesolimbic pathway is responsible for the positive 
symptoms; the hypoactivity is res...
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NURS 4010 Unit 1 Exam Antipsychotic/Neuroleptic Medications Questions With Verified Answers
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NURS 4010 Unit 1 Exam Antipsychotic/Neuroleptic Medications Questions With Verified Answers 
Bind with dopamine receptors (commonly D2 receptors - in all 4 pathways of the brain, causing side effects) 
MOA of Antipsychotic/Neuroleptic Medications 
 
 
Antipsychotics 
Used for schizophrenia, paranoia, psychosis, mania, severe anxiety, Tourette's, autism; Note: just b/c someone is on an antipsychotic does not mean they have a thought disorder; Metabolized by the liver and excreted in urine, feces...
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Summary NSG 552 Psychopharmacology Exam 1 Study Guide LATEST 2024.
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Summary NSG 552 Psychopharmacology Exam 1 Study Guide LATEST 2024. 
DOPAMINE 
• Dopamine belongs to the family of catecholamines. It is a neurotransmitter. 
• Hormones, Epinephrine and Norepinephrine (other catecholamines) are derived from Dopamine 
• Dopamine plays a significant role in learning, goal-directed behavior, regulation of hormones, motor 
control. 
DOPAMINE SYNTHESIS 
Phenylalanine (amino acid from diet) -> phenyalanine hydroxylase -> Tyrosine -> Tyrosine hydroxylase ...
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NR 546 Week 3 Assignment; Antipsychotic Medications Table: (Solved) Guaranteed A+ Guide
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Drug name Indication 
Target symptoms: state if positive or negative effect 
Potency (if noted. receptor occupancy if noted ) 
Neurotransmitter(s) affected 
Half-life 
(T1/2), 
metabolism 
(CYP 450 
enzyme) 
Notable side effects (associate to pathway or NT) 
Typical antipsychotics (conventional) 
Haloperidol Dopamine Receptor Antagonist 
Targets the symptoms of psychosis such as hallucinations 
and delusions. It can also be used to treat the tics and 
vocalizations of Tourette’s, as a second-l...
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NR 546 weeks 3 antipsychotic table Chamberlain
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Drug name Indication 
Target symptoms: state if positive or negative effect 
Potency (if noted. receptor occupancy if noted ) 
Neurotransmitter(s) affected 
Half-life 
(T1/2), 
metabolism 
(CYP 450 
enzyme) 
Notable side effects (associate to pathway or NT) 
Typical antipsychotics (conventional) 
Haloperidol Treats positive symptoms 
Prescribed for manifestations of psychotic disorders, Tics 
and vocal utterances in Tourette’s syndrome 
Blocks dopamine 2 receptors, reducing positive 
symptoms ...
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ANCC PMHNP Exam Prep Questions and Answers (2024) (Verified Answers)
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ANCC PMHNP Exam Prep Questions and Answers (2024) (Verified Answers) 
mesocortical pathway 
executive function: attention, focus, depression 
 
 
nigrostriatal pathway 
from substantia nigra (brainstem) to striatum (muscles): Parkinson's 
 
 
mesolimbic pathway 
projects to nucleus accumbens (part of limbic system). Pleasure, reward, positive symptoms of schizophrenia: Addiction, gambling 
 
 
Tuberoinfundibular pathway 
regulation of prolactin (acts on pituitary). Hypersexuality in mania 
 
 
...
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NSG 552 Psychopharmacology Exam 1 Study Guide Complete Updated 2024/2025
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NSG 552 Psychopharmacology Exam 1 Study Guide Complete Updated 2024/2025. Phenylalanine (amino acid from diet) -> phenyalanine hydroxylase -> Tyrosine -> Tyrosine hydroxylase -> 
DOPA -> Dopa decarboxylase -> Dopamine 
KEY POINT: Dopamine is synthesized directly from tyrosine or indirectly from phenylalanine 
• Dopamine is packed and stored into synaptic vesicles via the vesicular monoamine transporter (VMAT2) 
and stored until its release into the synapse. 
• When dopamine...
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NR546 PSYCHOPHARM MIDTERM 2024 QUESTIONS WITH COMPLETE ANSWERS GRADED A+
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How does the orbitofrontal cortex (OFC) affect the amygdala? - CORRECT ANSWER inhibits and activates the amygdala 
Wernicke's area is associated with which of the following? - CORRECT ANSWER speech comprehension 
The limbic system is associated with which of the following - CORRECT ANSWER emotion and learning 
Which brain structure is most associated with long term memory? - CORRECT ANSWER hippocampus 
When prescribing psychotropic medications, the PMHNP knows that t...
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NURS 4010 Unit 1 Exam Antipsychotic/Neuroleptic Medications Questions With Verified Answers
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NURS 4010 Unit 1 Exam Antipsychotic/Neuroleptic Medications Questions With Verified Answers 
Bind with dopamine receptors (commonly D2 receptors - in all 4 pathways of the brain, causing side effects) 
MOA of Antipsychotic/Neuroleptic Medications 
 
 
Antipsychotics 
Used for schizophrenia, paranoia, psychosis, mania, severe anxiety, Tourette's, autism; Note: just b/c someone is on an antipsychotic does not mean they have a thought disorder; Metabolized by the liver and excreted in urine, feces...
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ANCC PMHNP Exam Prep Accurate 100%
- Exam (elaborations) • 5 pages • 2023
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mesocortical pathway - ANSWER executive function: attention, focus, depression 
 
nigrostriatal pathway - ANSWER from substantia nigra (brainstem) to striatum (muscles): Parkinson's 
 
mesolimbic pathway - ANSWER projects to nucleus accumbens (part of limbic system). Pleasure, reward, positive symptoms of schizophrenia: Addiction, gambling 
 
Tuberoinfundibular pathway - ANSWER regulation of prolactin (acts on pituitary). Hypersexuality in mania 
 
Dopamine - ANSWER produced in substania nigra ...
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