Lipinskis rule of 5 Study guides, Class notes & Summaries
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GMS6504/GMS 6504 University Of Florida -GMS 6504 CHAPTER 4 Questions With Complete Solutions
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GMS6504/GMS 6504 University Of Florida -GMS 6504 CHAPTER 4 Questions With Complete Solutions
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GMS 6504 Exam Questions and Answers 100% Correct
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GMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectLipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 
1. mass greater than 500 Da 
2. highly lipophilic - logP > 5 
3. more than 5 hydrogen bond donors 
4. more than 10 hydrogen bond acceptors 
 
Partition coefficient - ANSWER-p = C(octanol)/C(water) 
- ratio of the equili...
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GMS 6504 Exam With Questions And Accurate Answers 2024-2025
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GMS 6504 Exam With Questions And Accurate Answers ...
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GMS 6504 Exam Questions and Answers 100% Correct!!
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Lipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 
1. mass greater than 500 Da 
2. highly lipophilic - logP > 5 
3. more than 5 hydrogen bond donors 
4. more than 10 hydrogen bond acceptors 
 
Partition coefficient - ANSWER-p = C(octanol)/C(water) 
- ratio of the equilibrium concentrations of dissolved substance in a two-phase system containing two largely immiscible solvents (water & octanol) 
- Log10(P) 
 
Improved Lipinski Parameters - ANSWER-1. Partition...
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GMS 6504 Exam Questions and Answers 100% Correct
- Exam (elaborations) • 13 pages • 2024
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GMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectLipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 
1. mass greater than 500 Da 
2. highly lipophilic - logP > 5 
3. more than 5 hydrogen bond donors 
4. more than 10 hydrogen bond acceptors 
 
Partition coefficient - ANSWER-p = C(octanol)/C(water) 
- ratio of the equili...
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Introduction to drug discovery final exam Questions with Complete Solutions
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Lipinski's Rule of 5 - ANSWER-A successful drug meets these criteria: 
-LogP<5 
-molecular weight <500 g/mol 
- hydrogen bond donors <5 
-hydrogen bond acceptors <10 
-rotatable bonds<10 
 
logD - ANSWER-distribution between all forms of drug (logD<5) 
 
Polar surface area - ANSWER-the surface area of nitrogen's, oxygens, and their attached protons on a molecule 
 
What is the problem with Lipinski's rules - ANSWER-the majority of drugs that are being focused on only adhere ...
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HSS 3106 Midterm Exam With Complete Solution
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HSS 3106 Midterm Exam With Complete Solution...
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