Nigrostriatal pathway Study guides, Class notes & Summaries
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NR 546 Antipsychotics Table Week 3 Assignments.
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NR 546 Antipsychotics Table Week 3 Assignments. 
Drug name Indication 
Target symptoms: state if positive or negative effect 
Potency (if noted. receptor occupancy if noted) 
Neurotransmitter(s) affected 
Half-life (T1/2), 
metabolism (CYP 
450 enzyme) 
Notable side effects (associate to pathway or NT) 
Typical antipsychotics (conventional) 
Haloperidol Target symptoms: 
Manifestations of psychotic disorders 
Tics and vocal utterances in Tourette’s Syndrome 
Second-line treatment of severe beh...
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Maryville Psychopharmacology, Exam 1 Review
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How many dopamine pathways in the brain? - Answer - 5 but only 4 associated with schizophrenia 
 
Nigrostriatal Dopamine Pathway controls - Answer - motor function and movement (part of EP NS) 
 
Nigrostriatal Dopamine Pathway dopamine excess - Answer - Hyperkinetic movements such as tics/dyskinesias 
 
mesolimbic dopamine pathway controls - Answer - Pleasure, reward, euphoria of drug abuse and reinforcing behavior 
 
Mesolimbic dopamine pathway excess - Answer - delusions and hallucinations - p...
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Regis College PSYCH 643 - All Weeks Quizzes - Questions with Verified Answers
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Week 3 Quiz 
#1 is C. 
1. Volume neurotransmission refers to? 
The diffusion of neurotransmitter to nearby neurons. 
2. Retrograde neurotransmissions refers to? 
The flow of neurotransmitter from postsynaptic neuron to presynaptic neuron 
3. Use the following CYP450 table to hypothesize drug interactions and their clinical 
significance for a patient on clozapine who carbamazepine, a mood stabilizer? 
Clozapine levels would decrease, placing the patient at risk for re-emergence of 
psychotic sym...
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ANCC PMHNP Exam Prep
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mesocortical pathway – 
executive function: attention, focus, depression 
nigrostriatal pathway – 
from substantia nigra (brainstem) to striatum (muscles): Parkinson's 
mesolimbic pathway – 
projects to nucleus accumbens (part of limbic system). Pleasure, reward, 
positive symptoms of schizophrenia: Addiction, gambling 
Tuberoinfundibular pathway – 
regulation of prolactin (acts on pituitary). Hypersexuality in mania 
Dopamine – 
produced in substania nigra and VTA. D2 & D4 receptors ...
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ANCC PMHNP Exam Prep Question with complete solution 2023
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ANCC PMHNP Exam Prep Question with complete solution 2023mesocortical pathway 
executive function: attention, focus, depression 
 
 
 
nigrostriatal pathway 
from substantia nigra (brainstem) to striatum (muscles): Parkinson's 
 
 
 
mesolimbic pathway 
projects to nucleus accumbens (part of limbic system). Pleasure, reward, positive symptoms of schizophrenia: Addiction, gambling 
 
 
 
Tuberoinfundibular pathway 
regulation of prolactin (acts on pituitary). Hypersexuality in mania 
 
 
 
Dopam...
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LMR - Georgette's flashcard 2023/2024
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LMR - Georgette's flashcard 2023/2024 
 
 
LMR - Georgette's flashcard 2023/2024 
Terms in this set (526) 
 
 
What drugs should be avoided with Kava Kava?	 
Alprazolam 
CNS depressants (e.g., phenobarbital, zolpidem) 
 
What is the normal range for TSH?	 
0.5 - 5.0 mu/L 
 
What are lab values in Hyperthyroidism	 
Decreased TSH Increased T4 and T3 
 
What are labs in Hypothyroidism?	 
Increased TSH Decreased T4 and T3 
	 
Heat intolerance 
What are 5 primary symptoms of	Agitation, Anxiety, Irr...
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Exam (elaborations) NURS 660
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dopamine hypothesis - ANSWER the theory that schizophrenia results from excessive 
activity of the neurotransmitter dopamine 
dopamine hypothesis- nigrostriatal pathway - ANSWER The nigrostriatal dopamine 
pathway that projects from the substantia nigra to the basal ganglia or striatum, is part 
of the extrapyramidal nervous system and controls motor function and movement. 
Mesolimbic dopamine hypothesis: Hyperactivity of dopamine neurons in the mesolimbic 
dopamine pathway cause what sympto...
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NR 546 week 3 Assignment; Antipsychotics Medications Table 1&2 Updated 2023.
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NR 546 week 3 Assignment; Antipsychotics Medications Table 1&2 Updated 2023. Drug name Indication 
Target symptoms: state if positive or negative effect 
Potency (if noted. receptor occupancy if noted ) 
Neurotransmitter(s) affected 
Half-life (T1/2), 
metabolism 
(CYP 450 
enzyme) 
Notable side effects (associate to pathway or NT) 
Typical antipsychotics (conventional) 
Haloperidol Blocks dopamine 2 receptors, reducing positive 
symptoms of psychosis and possibly combative, 
explosive, and hyp...
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NURS 660 Exam 1 Study Guide 2023
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NURS 660 Exam 1 Study Guide 2023. Pathways in schizophrenia 
 Brain imaging shows cerebral atrophy and enlarged fluid filled ventricles, as well as 
shrinkage in prefrontal cortex, temporal, basal ganglia, and limbic regions like 
hippocampus. 
 Five dopamine pathways in the brain. The neuroanatomy of dopamine neuronal pathways 
in the brain can explain the symptoms of schizophrenia as well as the therapeutic effects 
and side effects of antipsychotic drugs. 
 Know different pathways in th...
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NR 546 Week 3: NR 546 Week 3 Study Guide: Updated Solution
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Indication 
Target symptoms: state if positive or negative effect Potency (if noted. receptor occupancy if noted ) Neurotransmitter(s) affected	Half-life (T1/2), metabolism (CYP 450 
enzyme)	Notable side effects (associate to pathway or NT) 
Typical antipsychotics (conventional) 
Blocks dopamine 2 receptors, reducing positive symptoms of psychosis and possibly combative, explosive, and hyperactive behaviors Blocks dopamine 2 receptors in the nigrostriatal pathway, improving tics and other sympto...
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