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BGZ2026 The Basic Principles of Pharmacology summary all cases

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  • Course
  • The Basic Principles of Pharmacology BGZ2026 (BGZ2026)
  • Institution
  • Maastricht University (UM)
  • Book
  • Rang

In this document, all cases of course BGZ2026 The Basic Principles of Pharmacology are included. The comments of the tutor are marked in red

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  • Unknown
  • October 1, 2020
  • 65
  • 2019/2020
  • Summary

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  • bgz2026 the basic principles of pharmacology health sciences health sciences year 2 maastricht university essay cases

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  • The Basic Principles of Pharmacology BGZ2026 (BGZ2026)
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BGZ2026 The Basic Principles of Pharmacology summary of all cases
Extensive summary of all cases with additional comments from the tutor
included

PROBLEM 1: THERAPEUTIC AND TOXIC EFFECTS OF COMPOUNDS – A
MATTER OF DOSE AND TIMING?

Problem statement:

Therapeutic and toxic effect of compounds – pharmacokinetics?



Brainstorm:

• Part 1A
Alcohol

The body and alcohol, body weight and composition

Into the liver: detoxication

Concentration per amount

Liver and kidney work them out of the body – metabolism

Coffee and waiting → how quickly is it broken down? Coffee influencing anything?

Enzyme function



• Part 1B
Multiple tablets → does the time of effect stretch?

Amount of enzymes

It may last longer, but not the double amount of time



• Part 1C
Overdoses of paracetamol → empty stomach

NAC

AST and ATL

Paracetamol level is 68 mg/ml → a high value

Metabolism → toxic



Learning goals:

1. What is the definition of pharmacokinetics?
2. What does ADME mean? (Absorption) (Distribution) (Metabolism) (Elimination)
3. What parameters describes the pharmacokinetics (volume of distribution, the clearance,
half-life of the drug, elimination constant and the absorption constant), T-max and C-max

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