PCB 3233 - Immunology Exam 3 Practice
Questions and Answers (100% Pass)
Helper T cells associate with which class of MHC molecules? -
Answer️️ -MHC Class 2 (extracellular infection)
Interferon function - Answer️️ -Viral fighting, they activate NK cells
which then tell our infected cell...
PCB 3233 - Immunology Exam 3 Practice
Questions and Answers (100% Pass)
Helper T cells associate with which class of MHC molecules? -
Answer✔️✔️-MHC Class 2 (extracellular infection)
Interferon function - Answer✔️✔️-Viral fighting, they activate NK cells
which then tell our infected cells to die by apoptosis.
What process creates the variable region domain for both TCRs and
BCRs? - Answer✔️✔️-Somatic Recombination
What the different types IFN-1? - Answer✔️✔️-Alpha and Beta
What are the differences and similarities between CD8 T Cells and
NK cells? - Answer✔️✔️-The both have the same cytotoxic granules,
NK cells are activated faster, because they come out of the bone
marrow "ready to go". CD8 T cells recognizes MHC Class 1 + peptide
(antigen) on a pathogen, while NK cells recognize normal MHC Class
1 molecules on the surface of our cells and activating ligands that
infected cells put up on their surface.
2 types of activating ligands - Answer✔️✔️-MIC - A and MIC - B, they
bind to activating receptors on activating NK cells
Type 2 interferon - Answer✔️✔️-Also know as IFN- gamma, activates
macrophages
IL - 12 - Answer✔️✔️-Inflammatory cytokine that activates NK cells
which then produces IFN - gamma which then activate
macrophages.
Which complement receptors can recognize C3b? - Answer✔️✔️-CR 1
- CR 4
Which Professional Antigen Presenting Cell (Professional - APC) is
strong enough to activate a CD8 T cell from a naive state? -
Answer✔️✔️-Dendritic cells
C3 convertase of the Alternative Pathway - Answer✔️✔️-C3bBb
When will NK cells make interferon gamma? - Answer✔️✔️-When
they are activated by IL-12 (inflammatory cytokine)
Explain the activation of macrophage feedback loop - Answer✔️✔️-NK
cells become activated by IL- 12, they produce interferon gamma,
IFN- gamma activates macrophages, macrophages secrete IL-12 (+
other cytokines)
Describe the chains in a TCR? - Answer✔️✔️-V region followed by a C
region followed by a membrane anchoring domain
Where is the most variable region of the TCR? - Answer✔️✔️-V-alpha
and V- beta
2
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