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TEST BANK FOR JANEWAYS IMMUNOBIOLOGY / COMPLEMENT SYSTEM/ Q& A/ 100% GUARANTEED PASS/ ALREADY RATED A What is complement? - ANSWER a group of blood and cell surface proteins that are important to inflammatory and immune responses Describe the complement cascade following activation via the ...

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  • August 21, 2024
  • 4
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • test bank for immunobiology exam

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  • Immunology
  • Immunology

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TEST BANK FOR JANEWAYS IMMUNOBIOLOGY /
COMPLEMENT SYSTEM/ Q& A/ 100%
GUARANTEED PASS/ ALREADY RATED A+


What is complement? - ANSWER a group of blood and cell surface proteins that are important to
inflammatory and immune responses



Describe the complement cascade following activation via the classical pathway - ANSWER Complement
activation via any pathway will cause cleavage of C3 to C3a and C3b. C3b will covalently bind to surface
components of the pathogen and then lead to death via one of the following courses:

- Recruitment of inflammatory cells

- Opsonization of pathogens, facilitating uptake and killing by phagocytes

- perforation of pathogen cell membrane



What differentiates the classical, the alternative and the lectin pathways of complement activation -
ANSWER 1. Alternative pathway:

- first to activate

- Creates a local environment that is conducive to complement activation

- C3bBb Convertase & C3b₂Bb for MAC will generate C3b



2. Lectin pathway:

- second to act

- Mannose binding lectin binds to pathogen

- Mannose is found in microbes and fungus not human cells.

- MASP-1 and MASP-2

- C4bC2a will generate C3b



3. Classical pathway:

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