Naplex things to remember correctly
answered 2023
CYP INHIBITORS - correct answer **G PACMAN**
Grapefruit
Protease inhibitors (Ritonavir)
Azole antifungals
C - cyclosporine, cimetidine, cobicistat
Macrolides (NOT azithromycin)
Amiodarone (and dronedarone)
Non-DHP CCBs
CYP INDUCERS - correct answer **PS PORCS**
Phenytoin
Smoking
Phenobarbital
Oxcarbazepine (and eslicarbazepine)
Rifampin
Carbamazepine (also auto-inducer)
St. Johns wort
Digoxin Levels - correct answer 0.8-2 (Afib)
0.5-0.9 (HF)
Toxicity:
Initial s/sx: N/V, loss of appetite, bradycardia
Severe s/sx: blurred/double vision, greenish-yellow halos
FDA Orange Book - correct answer List approved drugs that can be interchanged with
generics based on therapeutic equivalence
CDC Pink Book - correct answer Info on epidemiology and vaccine preventable
diseases
Pink SHEET - correct answer News reports on regulatory, legislative, legal and
business developments
FDA Purple Book - correct answer List of biological drug products, including biosimilars
RED BOOK (Pharmacy) - correct answer drug pricing
Red Book (pedes) - correct answer Summaries of pediatric infectious diseases, abx
treatment and vaccines
,CDC Yellow Book - correct answer Info on the health risk of international travel,
required vaccines and prophylaxis meds
FDA Green Book - correct answer Info on approved animal drug products
Drugs that require PCV containers - correct answer **Leach Absorbs To Take In
Nutrients**
Lorazepam
Amiodarone
Tacrolimus
Taxanes
Insulin
Nitroglycerin
Drugs with FILTER requirements - correct answer my ***GAL, PLAT*** needs a filter
Golimumab (simponi)
Amiodarone
Lorazepam
Phenytoin
Lipids - 1.2 micron
Amphotericin B (lipid formualtions)
Taxanes (except docetaxel)
PROTECT FROM LIGHT - correct answer **Protect Every Necessary Med from
Daylight**
Phytonadione (Vit K, Mephyton)
Epoprogestenol
Nitroprusside
Micafungin
Doxycycline
SALINE ONLY - correct answer **A DIAbetic Can't Eat Pie**
Ampicillin
Daptomycin
Infliximab
Ampicillin/Sulbactam
Caspofungin
Ertapenem
Phenytoin
DEXTROSE ONLY - correct answer ***BOAS like dextrose***
Bactrim
Oxaliplatin
Amphotericin B
,Synercid (Quinupristin/Dalfopristin)
DO NOT REFRIDERATE - correct answer **Dear Sweet Pharmacist, Freezing Makes
Me Edgy**
Dexamedetomidine (Precedex)
Sulfa/Trimeth (Bactrim)
Phenytoin
Furosemide
Metronidazole
Moxifloxacin
Enoxaparin
Common LIVE vaccines - correct answer **COZY IV RM***
Cholera (PO) (Vaxchora)
Oral Typhoid (PO) (Vivotif)
Zoster (Zostavax)
Yellow Fever
Intranasal Influenza (Flu-Mist)
Varicella (Varivax)
Rotavirus (PO) (Rotarix, Rotateq)
MMR
pneumococcal vaccines - correct answer 13 Valent Conjugate Vaccine (PCV 13) -
PREVNAR 13
- Patients should only receive 1 dose in their lifetime
- Given IM Routinely
- indicated in children < 5 Give
1 dose if never received:
-Immunocompromised patients 6-64 yo
- Can be considered in patients age ≥ 65 (provider discussion)
23 Valent Polysaccharide Vaccine (PPSV 23) - PNEUMOVAX 23
- Patients may receive 1,2, or 3 doses in their lifetime
- Given IM or SQ
- Give 1 dose before age 65: immunoCOMPETENT age 2-64 (diabetes, heart, lung, or
liver disease, alcohol abuse, smoker)
- Give 2 doses before age 65 Immunocompromised 2-64 yo Sickle cell disease,
asplenia, HIV
- Give 1 dose at age ≥65 ALL patients
PPSV23 ---> PPSV 23: SEPARATE BY 5 YEARS
PCV 13 ---> PPSV 23: SEPARATE BY 1 YEAR
**UNLESS - immunocompromised - 8 weeks
Flu Vaccine - correct answer Given annually unless -
Age 6 months - 8 years (previously not vaccines) GIVE 2 DOSES (4 weeks apart)
All pts ≥6 months
All brand names have FLU in the name (Afluria, Fluzone, FluMist, Fluarix, FluLaval)
, HIGH DOSE (≥65): Fluad, Fluzone High Dose (both only Trivalent) and Fluzone High
Dose Quadrivalent & Flublock Quadravalent
Flublok (egg free) is approved for ≥18 yo
Do not admin live intranasal influenza vaccine (FluMist) in egg allergy patients
Flu Mist (LAIV4): healthy people aged 2-49 yo
Immunizations allergy CI - correct answer Yellow fever: CI with severe allergy to eggs
or gelatin
Varivax/Zostavax: hypersensitivity to gelatin or neomycin
Tylenol and Motrin dose in CHILDREN - correct answer Tylenol: 10-15 mg/kg/dose q 4-
6h (160mg/5mL)
Motrin: 5-10 mg/kg/dose q6-8h
Morphine and Hydromorphone conversions - correct answer Morphine 10mg IV = 30
mg PO =
Hydromorphone 1.5 mg IV = 7.5 mg PO
Pregnancy Treatment for:
HTN
UTI
Hyperthyroidism
Hypothyroidism - correct answer HTN: (LMN) - labetalol, methyldopa, nifedapine
UTI: cephalexin or ampicillin
Hyper: PTU (1st tri), Methimazole (2&3rd)
Hypo: increase levothyroxine dose by 30-50%
ED PDE-5 dosing - correct answer Reduce start dose by 50% if:
- ≥65 Using alpha blocker
- Using CYP 3A4 inhibitor
- Severe renal or liver disease
DOSES:
Viagra (sildenafil) = 50 mg --> 25 mg
Cialis (Tadalafil) /Levitra (Vardenafil) = 10 mg --> 5 mg
Stendra (Avanafil) = 100 mg --> 50 mg
alpha 1 blockers
5 alpha reductase inhibitors - correct answer doxazosin, terazosin (nonselective),
tamsulosin, alfuzosin, silodosin (selective)
finasteride, dutasteride
Vassopressors and extravastation antidote - correct answer Dopamine, Epinephrine,
NE, phenylephrine, vasopressin (all alpha 1 agonist)
phentolamine (alpha 1 blocker)
Dopamine dosing - correct answer LOW (renal) 1-4 = dopamine 1 agonist
